Season 1

In this first episode of “Intention to Treat,” NEJM editor-in-chief Eric Rubin and his colleague at the FDA Vaccine Advisory Committee, Paul Offit, consider the achievements, limitations, and expectations of Covid vaccines.
 
A transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2300222.

In this episode of “Intention to Treat,” host Rachel Gotbaum takes us to Tennessee and Ohio, where new abortion bans are already harming patients and threatening their physicians.
 
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2300935.

In this episode of “Intention to Treat,” a study participant and a long-time investigator of hallucinogenic drugs for psychiatric conditions illuminate the effects of psilocybin in patients with depression.
A full transcript of this episode is available at https://www.nejm.org/doi/full/10.1056/NEJMp2300936.

In this episode of “Intention to Treat,” some of the people who have worked closely with “America’s Doctor,” Anthony Fauci, offer insights into his character, values, accomplishments, and adventures over his decades of service at the NIH.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2300937.

In this episode of “Intention to Treat,” Anthony Fauci sits down with host Rachel Gotbaum to discuss his long career in infectious disease and public health, what has motivated him, and the lessons he has learned and taught along the way.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2300938.

In this episode of “Intention to Treat,” Maia Hightower and Isaac Kohane join host Rachel Gotbaum to explore the promise and hazards of artificial-intelligence and machine-learning tools for both clinical and administrative uses in medicine.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2301939.

In this episode of “Intention to Treat,” host Rachel Gotbaum talks with patient Robert Schlamberg and Doctors Oladapo Yeku and Oliver Sartor about the option of watchful waiting in the care of men with early prostate cancer.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303613.

This episode of “Intention to Treat” tells the story of the Freedom House Ambulance Service — a group of Black laypeople in Pittsburgh who underwent intensive training to become the first paramedics in the United States.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303614.

In this episode of “Intention to Treat,” Drs. Harvey Fineberg and Eric Rubin take stock of the failures and successes of the Covid-19 response and elucidate their lessons for combating the next major public health threat, whatever it may be.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303615.

“Intention to Treat” host Rachel Gotbaum talks with patient Awilde Peña and oncologist Deb Schrag about a new approach to treating rectal cancer that sidesteps the need for radiation, thereby avoiding long-term side effects and preserving fertility.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303850.