Season 1

In this episode of “Intention to Treat,” host Rachel Gotbaum explores the story of a teenager who’s now in remission from previously relapsed lymphoblastic leukemia and talks with the investigator who developed the “off-the-shelf” CAR T cells that made her treatment possible.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303851.

This episode of “Intention to Treat,” explores the crisis in primary care in the United States, as increasing numbers or primary care physicians leave the field — driven out by corporatization, growing time pressure, and the inability to form the relationships that enable good care.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2303852.

What is driving U.S. physicians out of primary care — and keeping trainees from going into it in the first place? In this episode of “Intention to Treat,” host Rachel Gotbaum explores the breakdown of the system and possible ways to save it.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2305758.

Some types of pain have proven resistant to all available medications. In this episode of “Intention to Treat,” Rachel Gotbaum talks with a patient with neuropathic pain and a researcher exploring new sodium-channel blockers that offer promise for such patients.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2305759.

People living with HIV have increased risk for cardiovascular disease (and other diseases of aging) earlier in life than those without HIV. In this episode of “Intention to Treat,” researcher Steven Grinspoon describes a new strategy for preventing collateral damage.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2307347.

Cardiologists now recognize that heart failure with preserved ejection fraction (HFpEF) may be caused by obesity. This episode of “Intention to Treat” examines new evidence that treating obesity can prevent HFpEF.
 
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2307349.

In this episode, a patient with narcolepsy describes her rough, long road to diagnosis and treatment, and a researcher elucidates both the condition and a new therapeutic direction.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2308308.

This episode peers into U.S. schools to examine a widespread but non–evidence-based approach to preparing children and staff for gun-violence incidents.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2308309.

This episode explores long Covid, an often-disabling but unexplained syndrome of post-acute sequelae of SARS-CoV-2. How is it affecting millions of people, and what is being done about it?
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309483.

Host Rachel Gotbaum talks with a patient with early-onset Alzheimer’s disease and two dementia experts about frustrations with the current state of Alzheimer’s care.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309485.