Season 1

This episode explores the current state of research on the multiple likely mechanisms of Alzheimer’s disease as well as promising treatments and diagnostics.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309944.

This episode examines the need for and promise of xenotransplantation, considering first the plight of patients and then the progress being made by researchers.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2309946.

This episode examines Covid-19 variants that are currently circulating, recommendations for booster shots, and new treatments in the pipeline.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2311327.

Over its 200-plus years, the Journal has sometimes published articles that have perpetuated injustices against various groups of people. A new Perspective series explores that history and its lessons.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2311329.

In the second half of our podcast series on historical injustices, guests Evelynn Hammonds and David Jones examine the racism of post-World War II American medicine and its lessons for the present day.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314000.

Highlighting gaps in communication near the end of life, this podcast episode explores a new approach to preparing patients with serious illness and their families for all possible outcomes.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314001.

In this episode, parents who have lost children to gun accidents and physicians working for gun safety discuss the number-one killer of U.S. children and what doctors can do about it.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2314002.

This episode explores the fastest-growing neurologic condition in the world, Parkinson’s disease. What have we learned in recent years, and where are the greatest hopes for the future?
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2414003.

This episode considers a new treatment for hypertrophic cardiomyopathy, the world’s most common inherited heart condition, which most affected people don’t even realize they have.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2400702.

In the face of a growing childhood obesity epidemic, some parents and clinicians are turning to new tools such as GLP-1 receptor agonists. This episode explores the implications of that trend.
A full transcript of this episode is available at nejm.org/doi/full/10.1056/NEJMp2400703.